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Adrenal Tumor Producing Sex Hormones in a 14-Year-Old Dog

Reader Question
My dog was recently diagnosed with Atypical Cushings. He had all the symptoms of a cushinoid dog, but after doing the all day blood test, his cortisol levels were normal. He had an ultrasound which showed a mass on the adrenal gland. I then had the vet run another set of blood tests that test for several other hormones. The result was a highly elevated amount of progesterone. I believe the normal amount is on the high end 1.4 and my dog, Max, was at 18!

The vet is recommending surgery over medication. She said that since it's his left adrenal gland that has the tumor, it's easier to get to surgically. Also, she said that the meds would basically "kill" both his adrenal glands and then it would be a balancing act of meds he would need to be on the rest of his life.

My question is, after reading about the adrenalectomy, it seems like it is a very risky surgery. My dog is about 14 years old. I don't know if I should go ahead with it or wait it out....

Any advise would be much appreciated!


Answer from Our Team

Some adrenal tumors produce sex hormones such as progesterone instead of cortisol and cause Cushing's-like signs. Removing the affected adrenal gland can cure it, but adrenal surgery is a major operation with real risk, especially in older dogs, so your hesitation is understandable.

Ask for a CT scan to check whether the tumor is invading nearby vessels, and consider a consultation with a board-certified surgeon about his specific risk. Medical options such as trilostane or mitotane are sometimes used for these tumors, though evidence for them is limited and they don't remove the tumor. A specialist can help you weigh surgery against medication given his age and overall health.

See adrenal gland problems in dogs.

This is general information, not a diagnosis. Please follow your own vet's advice.

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