Pyoderma (Staph Skin Infection) in Dogs

Key takeaways

  • Pyoderma is a bacterial skin infection, usually caused by Staphylococcus pseudintermedius.
  • An underlying cause, such as allergies, is almost always present.
  • Chlorhexidine shampoos, wipes or sprays are first choice for surface and superficial infections.
  • Antibiotic pills are kept for deep infections or topical failure.
  • Wash your hands; dog staph can occasionally pass to people.

Pyoderma means "pus in the skin." It's a bacterial skin infection in dogs, usually caused by Staphylococcus pseudintermedius, a staph bacterium that normally lives on dog skin.1,2,3 It almost always develops because of another problem, most often allergies, parasites, hormone disease or skin folds.2,1 Signs include red bumps, pustules, crusts, rings of peeling skin and patchy hair loss. Deep pyoderma also causes pain, swelling, odor and draining blood or pus.4,5 Under 2025 international guidelines, antiseptic shampoos, wipes or sprays, usually chlorhexidine, are the first choice for surface and superficial pyoderma. Antibiotic pills are kept for deep infection or cases that don't respond.2,6 Methicillin-resistant staph (MRSP) is a growing problem, and dog staph can occasionally pass to people, so hand washing matters.7,8

See a vet promptly if your dog has:

  • Painful, swollen skin, open sores or draining blood or pus, which suggest deep pyoderma5,1
  • Fever, lethargy or poor appetite along with skin sores5
  • An infection that isn't improving after 2 weeks of treatment, or comes back soon after4,9
  • A past resistant (MRSP) infection, or a pet in the home that had one4,7

What the Research and Guidelines Say

  • Topical first. A guideline co-author writes that for superficial pyoderma "there are no clinical reasons to use systemic over topical antimicrobial therapy alone."9
  • As good as pills. In a randomized, blinded trial, 4% chlorhexidine shampoo plus solution "appeared as effective as systemic antibiotic therapy," and it also seemed to work in dogs with resistant staph.10
  • Shorter courses. The 2025 guidelines found "no evidence to support extending systemic antimicrobial therapy beyond the resolution of clinical signs."9,6
  • Resistance varies widely. MRSP made up 7.1% of S. pseudintermedius samples from dogs in a 2024 German study of 3,491 practices, and 23.9% of S. pseudintermedius isolates, mostly from dogs and cats, at a US Midwest diagnostic laboratory.11,12

Types of Pyoderma

  • Surface pyoderma: infection on the skin surface, including hot spots and skin-fold infections. Skin-fold dermatitis is most common in English Bulldogs, French Bulldogs and Pugs.2,13
  • Superficial pyoderma: infection of the hair follicles (superficial bacterial folliculitis), the most common form. Puppy pyoderma (impetigo) causes pustules on the hairless belly of young dogs.4,2,5
  • Deep pyoderma: infection below the follicles, with pain, swelling, crusts and draining tracts. It's more serious and needs prompt treatment.5,1

What Causes Pyoderma?

Staph bacteria live on normal dog skin and cause infection when the skin's defenses break down.5,2 Common triggers include:

  • Allergies (atopic dermatitis, food allergy, flea allergy)14,1
  • Fleas and mites1,2
  • Hypothyroidism and Cushing's disease1,5
  • Skin folds, pressure points such as elbows, and poor grooming1
  • Steroid medicines and incomplete treatment courses, which are linked to repeat infections1,5

Symptoms

  • Red bumps and pustules, usually around hair follicles4
  • Crusts, scale and rings of peeling skin (epidermal collarettes)4,1
  • Patchy, "moth-eaten" hair loss, and welts that look like hives in short-haired breeds4,1
  • In deep pyoderma: "pain, crusting, odor, and secretions of blood and pus"1

Diagnosis

Your vet will examine the skin and take cytology samples to confirm bacteria are present before using antibiotics.6,2 A bacterial culture and sensitivity test is recommended for deep infections, for infections that don't improve, for dogs with recent or repeated antibiotic use or resistant infections, and whenever antibiotic pills are planned.2,6,7 Your vet will also look for the underlying cause, such as skin scrapings for mites, allergy workups and hormone tests.2,5

Treatment

  • Surface and superficial pyoderma: chlorhexidine (2 to 4%) shampoos, wipes or sprays are the first choice, usually without antibiotic pills.2,9,15
  • When pills are needed: for deep pyoderma, when topical treatment isn't possible, or when topical treatment hasn't worked after 2 weeks. Vets choose from first-line antibiotic classes, ideally guided by a culture.6,9
  • How long: superficial infections are rechecked after about 2 weeks and deep infections after about 3 weeks. Treatment stops when the skin and cytology are clear, and courses longer than 6 weeks are rarely needed.6
  • Hot spots and skin-fold infections: cleaning, antiseptics and sometimes a short anti-inflammatory medicine.9,2
  • The underlying cause must be treated, or the infection "will inevitably come back."9

Older advice to continue antibiotics for a week after the skin looks normal comes from 2014 guidelines and has been replaced.4,6 Always follow your vet's instructions on how long to treat.

Resistant Staph (MRSP)

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) resists many common antibiotics. It isn't more aggressive than ordinary staph, but treatment options are fewer.7 Risk factors include past antibiotics, past resistant infections, recent hospital stays and living with a pet or person who had one.7,16 Topical chlorhexidine works against MRSP, and topical treatment can be the only treatment needed for surface and superficial MRSP infections.7,10

Can People Catch It?

Pyoderma itself isn't considered contagious in the usual sense, and dog staph rarely infects people.7 It can, however, pass to owners. A 2023 review found that about 4 to 6% of dog owners and vets carried it, and rare human infections are often misidentified as S. aureus.8 Wash your hands after touching infected skin, especially if anyone in the home has a weak immune system.7,8

Preventing Repeat Infections

  • Control allergies, fleas and other underlying causes.6,1
  • Ask your vet about regular antiseptic bathing for dogs that keep getting infections.6
  • Keep skin folds clean and dry, and keep up with grooming.1
  • Give the full treatment your vet recommends, and go to rechecks.6,1

Related: staph bacteria are the main cause of lip fold infections in spaniels and other droopy-lipped breeds. See lip fold dermatitis in dogs.

Frequently Asked Questions

Is pyoderma in dogs serious?

Superficial pyoderma is common and treatable. Deep pyoderma is more serious and can be painful.

How long does pyoderma take to clear up?

Superficial cases are usually rechecked after 2 weeks of treatment; deep cases take longer.

Is dog staph contagious to humans?

Rarely. It can pass to owners, so wash your hands after touching infected skin.

What can I put on my dog's staph infection?

Chlorhexidine shampoos, wipes or sprays are usually first choice. Ask your vet before using any cream.

Why does my dog keep getting staph infections?

Usually because an underlying problem, such as allergies, hasn't been fully controlled.

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Sources and further reading

This article was rewritten and fact-checked on October 23, 2026 against current veterinary references and specialist guidelines:

  1. Moriello KA. Pyoderma in Dogs. Merck Veterinary Manual (pet owner version), updated September 2024.
  2. Loeffler A, Cain CL, Ferrer L, Nishifuji K, Varjonen K, Papich MG, Guardabassi L, Frosini SM, Barker EN, Weese JS. Antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID). Veterinary Dermatology, 2025.
  3. Tanveer M, et al. Prevalence of bacterial pathogens isolated from canines with pyoderma and otitis externa in Korea: a systematic review and meta-analysis. Veterinary Sciences, 2024.
  4. Hillier A, Lloyd DH, Weese JS, et al. Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases). Veterinary Dermatology, 2014.
  5. Clark MD. Pyoderma in Dogs and Cats. Merck Veterinary Manual, updated October 2025.
  6. Loeffler A, Cain CL, Ferrer L, et al. Synopsis of the antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID). Veterinary Dermatology, 2025.
  7. Morris DO, Loeffler A, Davis MF, Guardabassi L, Weese JS. Recommendations for approaches to meticillin-resistant staphylococcal infections of small animals: diagnosis, therapeutic considerations and preventative measures. Veterinary Dermatology, 2017.
  8. Moses IB, Santos FF, Gales AC. Human colonization and infection by Staphylococcus pseudintermedius: an emerging and underestimated zoonotic pathogen. Microorganisms, 2023.
  9. Weese JS. ISCAID Canine Pyoderma Antimicrobial Use Guidelines Update, Part 2: Superficial Bacterial Folliculitis. Worms & Germs Blog, May 2025.
  10. Borio S, Colombo S, La Rosa G, et al. Effectiveness of a combined (4% chlorhexidine digluconate shampoo and solution) protocol in MRS and non-MRS canine superficial pyoderma (journal scan). Veterinary Dermatology, 2015 (via dvm360).
  11. Feuer L, Frenzer SK, Merle R, et al. Comparative analysis of methicillin-resistant Staphylococcus pseudintermedius prevalence and resistance patterns in canine and feline clinical samples: insights from a three-year study in Germany. Antibiotics, 2024.
  12. Adiguzel MC, Schaefer K, Rodriguez T, Ortiz J, Sahin O. Prevalence, mechanism, genetic diversity, and cross-resistance patterns of methicillin-resistant Staphylococcus isolated from companion animal clinical samples submitted to a veterinary diagnostic laboratory in the Midwestern United States. Antibiotics, 2022.
  13. O'Neill DG, et al. Ironing out the wrinkles and folds in the epidemiology of skin fold dermatitis in dog breeds in the UK. Scientific Reports, 2022.
  14. Hoff S. Atopic Dermatitis in Dogs. Merck Veterinary Manual, updated May 2026.
  15. Bensignor E, et al. Efficacy of chlorhexidine-impregnated wipes for local dysbiosis in atopic dogs. Veterinary Sciences, 2024.
  16. Putriningsih PAS, et al. Methicillin-resistant staphylococci in canine pyoderma in Thailand. Veterinary World, 2023.

About this article

Last updated : fully rewritten using the 2025 ISCAID canine pyoderma guidelines, the WAVD meticillin-resistant staphylococci consensus, the Merck Veterinary Manual and 2022 to 2026 resistance research, plus International Veterinary Information Service (IVIS) proceedings and research published 2022 to 2026.

This page is for general information and is not a substitute for an exam by your veterinarian.