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Liver Cancer, or Inflammation? Which Tests Before a Liver Biopsy?

Reader Question
My dog seems to be baffling vets in 3 states! He was diagnosed with Liver cancer last week, and this week they are not so sure. They biopsied his lymph glands, as they were enlarged, but those came back as just being inflamed. Now they are thinking he has 2 things going on, one possibly being an inflammatory disease, and the other being 'neoplastic'? He was extremely ill almost 2 weeks ago, with vomiting, nausea, and diarrhea. He was rushed to the vet for an injection to stop the nausea, given IV fluids, and has been on stomach meds since. I just wondered if ANYONE had a case similar to my dog's, and what was done to treat it. We have stacks of records that I would be willing to share. We are scheduled for another blood panel tomorrow, and a liver biopsy on Tuesday. If there are any specific blood tests that should be added to the panel test, please let me know and we'll add them. (I know that my vet would be willing to communicate with anyone who could be helpful to us, and I know that she could be far more technical, which may help us achieve the correct diagnosis and treatment for him.) Thanks so much!


Answer from Our Team

We're sorry you're going through so much uncertainty. It's common for a liver mass to be hard to label before a biopsy. Ultrasound and blood tests can't always tell cancer from inflammation or benign growths, and in one study about a quarter of liver masses that were removed turned out not to be cancer.

A liver biopsy is the right next step for a definite answer. Before a biopsy, vets check how well a dog's blood clots, usually with a platelet count, fibrinogen, a red cell count (PCV) and clotting times (PT and aPTT). Biopsies should include enough tissue from more than one area, and vets often also send samples for bacterial culture and copper measurement to look for causes of inflammation.

Your vet can also discuss whether CT imaging or a referral to a veterinary internal medicine specialist or oncologist would help. Bring your records, and write down your questions before the appointment.

See liver cancer in dogs and liver disease in dogs.

This is general information, not a diagnosis. Please follow your own vet's advice.

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